Antibacterial agents against d,d- and l,d-transpeptidases
AssigneeThe Johns Hopkins University
InventorsCraig A. Townsend, Evan Lloyd
Life of this patent
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Abstract
Antibacterial agents against D,D- and L,D-transpeptidases are disclosed. Pharmaceutical compositions and methods of using the same also are disclosed.
Claims19
A compound of formula (I):
- wherein:
- X is selected from the group consisting of CR′R″ and S;
- R′ and R″ are each independently selected from the group consisting of hydrogen, and C1-C6 alkyl;
- R is selected from the group consisting of:
- a is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5 and 6;
- b is an integer selected from the group consisting of 0, 1, 2, and 3;
- R1 is selected from the group consisting of hydrogen, and C1-C6 alkyl, C6-C12 aryl, and C4-C16 alkylaryl;
- Q is selected from the group consisting of hydrogen, hydroxyl, alkoxyl, amine, carbonyl, carboxyl, ester, ether, thiol, sulfide, sulfinyl, sulfonyl, and heterocycloalkyl;
- P is selected from the group consisting of amine, sulfide, sulfonyl, and sulfinyl;
- and stereoisomers and pharmaceutically acceptable salts thereof.
A method of treating, or preventing a bacterial infection in a subject comprising administering to the subject a therapeutically effective amount of a compound of formula (I), stereoisomer, or pharmaceutically acceptable salt thereof.
A method of inhibiting the growth of a bacteria in vitro comprising contacting the bacteria with an effective amount of a compound of formula (I), stereoisomer, or pharmaceutically acceptable salt thereof.
A method of inhibiting L,D-transpeptidase activity in a subject with a bacterial infection, comprising administering to the subject an effective amount of a compound of formula (I), stereoisomer, or pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of formula (I) and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.