In vitro heparin and heparan sulfate compositions and methods of making and using
AssigneeTEGA Therapeutics, Inc.
InventorsCharles GLASS, Bryan THACKER, Jeffrey ESKO
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Abstract
Disclosed herein are cellular derived heparin and heparan sulfate compositions, methods of making and using, and cell lines for making and using.
Claims60
A composition comprising heparin, wherein the composition is at least 99.5% free of chondroitin sulfate.
A composition comprising heparan sulfate, wherein the composition is at least 99.5% free of chondroitin sulfate.
A composition comprising a cell deficient in one or more genes recited in Table 6.
A method of making a cell line capable of producing a heparin or a hyper-sulfated heparan sulfate comprising genetically modifying a cell line to be transgenic or deficient for a gene of Table 6.
Dependencies are inferred from the claim text.