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US 2020/0032228 A1Published application
Variant of haloacid dehalogenase superfamily protein and method of reducing concentration of fluorine-containing compound in sample using the same
AssigneeSamsung Electronics Co., Ltd.
InventorsYukyung Jung, Taeyong Kim, Jinwoo Park, Joonsong Park, Jinsuk Lee, Changduk Kang, Jongwon Byun, Seunghoon Song
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Abstract
Provided are a variant of a haloacid dehalogenase superfamily protein, a polynucleotide encoding the variant, a recombinant microorganism including the variant, and a method of reducing a concentration of a fluorine-containing compound in a sample using the variant.
Claims20
A variant haloacid dehalogenase superfamily (HAD) protein comprising:
- substitution of an amino acid residue corresponding to position S184 of SEQ ID NO:
- 2, and substitution of at least one amino acid residue corresponding to positions N206, T208, and V210 of SEQ ID NO:
- 2;
- or
- substitution of at least one amino acid residue corresponding to positions N206, T208, or V210 of SEQ ID NO:
- 2,
- wherein the substitution of the amino acid residue corresponding to position S184 of SEQ ID NO:
- 2 is S184H, S184K, or S184R;
- the substitution of the amino acid residue corresponding to position N206 of SEQ ID NO:
- 2 is N206M, N206G, N206A, N206V, N206L, N206I, N206F, N206W, or N206P;
- the substitution of the amino acid residue corresponding to position T208 of SEQ ID NO:
- 2 is T208Q, T2085, T208C, T208Y, or T208N;
- and the substitution of the amino acid residue corresponding to position V210 of SEQ ID NO:
- 2 is V210D or V210E.
11 more elements
Dependencies are inferred from the claim text.