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US 2020/0030445 A1Published application
Stable formulations of humanized anti-tau antibody
AssigneeC2N Diagnostics
InventorsElizabeth John, Philip Verghese, Yan Hu, Matthias Kron, Katja Zipfel, Alexander Faude
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Abstract
Provided herein are stable compositions containing anti-tau antibodies. In particular, compositions containing C2N-8E12 anti-tau antibody and a buffering system are provided herein.
Claims19
A composition comprising:
- (i) a humanized antibody which specifically binds TAU comprising a heavy chain variable (VH) region and a light chain variable (VL) region;
- and
- (ii) a buffering system that optionally contains an excipient and/or optionally contains a surfactant.
A composition comprising:
- (i) a humanized antibody which specifically binds TAU comprising a heavy chain variable (VH) region as set forth in FIGS. 1 and 2 and a light chain variable (VL) region as set forth in FIGS. 1 and 2;
- and
- (ii) a buffering system comprising histidine, citrate, or glyclglycine, and that optionally contains an excipient and/or optionally contains a surfactant.
Dependencies are inferred from the claim text.