Composition comprising a bioactive molecule
AssigneeEucaryo Beheer B.V.
InventorWilhelmus Antonius Maria VAN LITH
Life of this patent
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Abstract
A process for preparing a composition including a bioactive molecule including the steps of a. Dissolving a bioactive molecule having at least one acid group with a base at pH=>11 to obtain a solution A b. Neutralizing the solution A with an acid to obtain the composition including the bioactive molecule having a pH between 6 and 9, wherein PEG is added before the neutralizing step in case either the base and/or the acid is an inorganic compound, and to a composition including a high concentration of natamycin.
Claims23
A process for preparing a composition comprising a bioactive molecule comprising the steps of:
- a. Dissolving a bioactive molecule having at least one acid group with a base at pH=>11 to obtain a solution A;
- and
- b. Neutralizing the solution A with an acid to obtain the composition comprising the bioactive molecule having a pH between 6 and 9, wherein PEG is added before the neutralizing step in case either the base and/or the acid is an inorganic compound, wherein the bioactive molecule is chosen from the group consisting of natamycin, amphotericin B, nystatin, filipin, giberrellic acid (GA3, GA4, GA7), auxin (indole-3-acetic acid, indole-3-butyric acid)—abcissic acid (S-ABA) and betulinic acid, and wherein the base is an organic base chosen from the group consisting of choline hydroxide, choline chloride, choline bitartrate, choline monohydrogen-tartrate, choline-dihydrogen-citrate, branched polyethyleneimine, tetramethylammonium hydroxide, tetraethylammonium hydroxide, and tetrabutylammonium hydroxide.
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A composition, comprising:
- a reaction product of 0.1-20 wt % of natamycin, 5-30 wt % of choline hydroxide and an organic acid, 5-90 wt % water and optionally 0-70 wt % PEG, wherein the organic acid is selected from propionic acid, fumaric acid, malic acid, tartaric acid and lactic acid.
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Dependencies are inferred from the claim text.