Methods for detection of tau protein aggregation modulating compounds
AssigneeJanssen Vaccines & Prevision B.V.
InventorsRosa CRESPO RODRIGUEZ, Constantin Adrian APETRI
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Abstract
The present invention provides a method for the in vitro formation and/or detection of paired helical filaments (PHF) of Tau protein, comprising incubating a mixture comprising a Tau protein preparation and a polyanionic co-factor for a pre-determined period of time under conditions that promote the formation of PHFs.
Claims20
A method for the in vitro formation of paired helical filaments (PHFs) of Tau protein, comprising incubating a mixture comprising a Tau protein preparation and a polyanionic co-factor for a pre-determined period of time under conditions that promote the formation of PHFs.
Dependencies are inferred from the claim text.