Foxc1 antibodies and methods of their use
AssigneeJohn Wayne Cancer Institute
InventorXiaojiang CUI
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Abstract
In one embodiment, an isolated antibody or functional fragment thereof which binds an antigenic peptide sequence of human FOXC1 is provided herein. Such antibodies or functional fragments may be used to diagnose, prognose or treat basal-like breast cancer. The antibody or functional fragment may be a monoclonal antibody produced by a hybridoma cell line. Thus, a hybridoma cell line that produces a FOXC1 monoclonal antibody which binds an antigenic peptide sequence of human FOXC1 as described above is also provided.
Claims9
1-20. (canceled)
A method of diagnosing a basal-like breast cancer in a subject having breast cancer or suspected of having breast cancer, the method comprising:
- contacting one or more breast cancer cells in a biological sample with an antibody or functional fragment thereof, wherein the antibody or functional fragment thereof binds an antigenic peptide sequence that is part of human FOXC1;
- detecting the presence or absence of FOXC1 in the one or more breast cancer cells;
- and
- diagnosing the subject as having a basal-like breast cancer when FOXC1 is present,
- wherein the antigenic peptide sequence is:
- 5′-AHAEQYPGGMARAYGPYTPQPQPKD-3′;
- (SEQ ID NO:
- 2)
- or
- 5′-C-AHAEQYPGGMARAYGPYTPQPQPKD-3′.
- (SEQ ID NO:
- 3)
Dependencies are inferred from the claim text.