Dispersive element in liquid chromatography systems
AssigneeWaters Technologies Corporation
InventorsMartin Gilar, Fabrice Gritti, Thomas S. McDonald
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Abstract
A liquid chromatography system including a solvent delivery pump for delivering a mobile phase through the liquid chromatography system, an injector for injecting a sample into the mobile phase, a column for effecting a separation of components of the sample, and a dispersive element positioned between the injector and the column, the dispersive element configured to dilute a sample solvent in the mobile phase prior to entering the column is provided. Further dispersive elements, systems, and methods are also provided.
Claims20
A dispersive element in a liquid chromatography system, the liquid chromatography system including a solvent pump, an injector, a column, and a detector, the dispersive element comprising:
- a pre-column body having an inlet end, an outlet end, and dispersing materials disposed therein, wherein the body is positioned between the injector and the column;
- wherein the dispersing materials dilute a mobile phase comprising a strong sample solvent prior to entering the column.
A liquid chromatography system comprising:
- a solvent delivery pump for delivering a mobile phase through the liquid chromatography system;
- an injector for injecting a sample into the mobile phase;
- a column for effecting a separation of components of the sample;
- and
- a dispersive element positioned between the injector and the column, the dispersive element configured to dilute a sample solvent in the mobile phase prior to entering the column.
A liquid chromatography system for controlled dispersion of a mobile phase, the liquid chromatography system comprising:
- a solvent delivery pump for delivering the mobile phase through the liquid chromatography system;
- an injector for injecting a sample into the mobile phase;
- a first flow path fluidically connecting the injector to a dispersive element, wherein a sample solvent is diluted by the dispersive element prior to the mobile phase entering the column;
- and
- a second flow path fluidically connecting the injector to the column to bypass the dispersive element.
Dependencies are inferred from the claim text.