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US 2020/0025686 A1Published application
Colorimetric assays
AssigneeEssenlix Corporation
InventorsStephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi
Life of this patent
Estimating the term…
Abstract
Among other thing, the present invention provides solution to the problem, particularly, the present invention provides means to improve the sensitivity, speed, and easy-to-use of a colorimetric assay.
Claims56
A device for enhancing optical signal in assaying a sample, comprising:
- a first plate, a second plate, spacers, and a textured surface, wherein:
- i. the first and second plates are movable relative to each other into different configurations, and have, on its respective inner surface, a sample contact area for contacting a sample that contains an analyte;
- ii. one or both plates are flexible;
- iii. the second plate has, on its inner surface, have textured structures that scatter the light illuminated on the surface, wherein the textured surface has an average roughness in the range 2 um˜5 um;
- iv. the spacers have a predetermined uniform height, and at least one of the spacers is inside the sample contact area;
- v. the preferred height of spacers is larger than the average roughness of the textured surface and smaller than 200 um;
- wherein on of the configuration is an open configuration, in which:
- two plates are partially or entirely separated apart, the spacing between the plates is not regulated by the spacers, and the sample is deposited on one or both of the plates;
- wherein on of the configuration is a closed configuration, which is configured after the sample deposition in the open configuration, and in the closed configuration:
- at least part of the deposited sample is compressed by the two plates into a continuous layer;
- wherein the sample is in liquid form.
8 more elements
A sample handling device for enhancing optical signal (Q-card), comprising:
- A first plate, a second plate, spacers and textured surface, wherein:
- i. the plates are movable relative to each other into different configurations;
- ii. one or both plates are flexible;
- iii. the second plate has, on its inner surface, have textured structures for scattering the light illuminated on the surface;
- iv. the textured surface can be, but is not limited to a bumpy, wavy roughly surface;
- v. the textured surface can be periodic or aperiodic;
- vi. the textured surface's average roughness range is preferred to be, but is not limited to 2 um˜5 um;
- vii. the spacers are fixed to the inner surface of the first plate and have a predetermined uniform height;
- viii. the preferred height of spacers is larger than the average roughness of the textured surface and smaller than 100 um;
- wherein on of the configuration is an open configuration, in which:
- two plates are partially or entirely separated apart, the spacing between the plates is not regulated by the spacers, and the sample is deposited on one or both of the plates;
- wherein on of the configuration is a closed configuration, which is configured after the sample deposition in the open configuration, and in the closed configuration:
- at least part of the deposited sample is compressed by the two plates into a continuous layer;
- wherein the sample is in liquid form.
11 more elements
A sample handling device for enhancing optical signal (Q-card), comprising:
- A first plate, a second plate, spacers and textured surface, wherein:
- i. the plates are movable relative to each other into different configurations;
- ii. one or both plates are flexible;
- iii. the second plate has, on its inner surface, have textured structures for scattering the light illuminated on the surface;
- iv. the textured surface can be, but is not limited to a bumpy, wavy roughly surface;
- v. the textured surface can be periodic or aperiodic;
- vi. the textured surface's average roughness range is preferred to be, but is not limited to 2 um˜5 um;
- vii. the spacers are fixed to the inner surface of the first plate and have a predetermined uniform height;
- viii. the preferred height of spacers is larger than the average roughness of the textured surface and smaller than 100 um;
- wherein on of the configuration is an open configuration, in which:
- two plates are partially or entirely separated apart, the spacing between the plates is not regulated by the spacers, and the sample is deposited on one or both of the plates;
- wherein on of the configuration is a closed configuration, which is configured after the sample deposition in the open configuration, and in the closed configuration:
- at least part of the deposited sample is compressed by the two plates into a continuous layer;
- wherein the sample is liquid form.
11 more elements
A sample handling device for enhancing optical signal (Q-card), comprising:
- a first plate, a second plate, spacers and textured surface, wherein:
- i. the plates are movable relative to each other into different configurations;
- ii. one or both plates are flexible;
- iii. the second plate has, on its inner surface, have textured structures for scattering the light illuminated on the surface;
- iv. the textured surface can be, but is not limited to a bumpy, wavy roughly surface;
- v. the textured surface can be periodic or aperiodic;
- vi. the textured surface's average roughness range is preferred to be, but is not limited to 2 um˜5 um;
- vii. the spacers are fixed to the inner surface of the first plate and have a predetermined uniform height;
- viii. the preferred height of spacers is larger than the average roughness of the textured surface and smaller than 100 um;
- wherein on of the configuration is an open configuration, in which:
- two plates are partially or entirely separated apart, the spacing between the plates is not regulated by the spacers, and the sample is deposited on one or both of the plates;
- wherein on of the configuration is a closed configuration, which is configured after the sample deposition in the open configuration, and in the closed configuration:
- at least part of the deposited sample is compressed by the two plates into a continuous layer;
- wherein the sample is in liquid form.
11 more elements
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Dependencies are inferred from the claim text.