Vitro Method and Apparatus for Analysing the Behaviour of Substances in Simulated Physiological Environment
AssigneeHoffmann-La Roche Inc.
InventorsHanns-Christian Mahler, Dhananjay Jagdish Jere, Sulabh Patel
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AssigneeHoffmann-La Roche Inc.
InventorsHanns-Christian Mahler, Dhananjay Jagdish Jere, Sulabh Patel
Estimating the term…
The invention refers to an in vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment. The method comprises the steps of providing a first fluid, a gel matrix and a second fluid, separating the first fluid and the gel matrix by at least one first semi-permeable membrane and separating the gel matrix and the second fluid by at least one second semi-permeable membrane. The method further comprises the steps of injecting a substance into the first fluid, letting the substance migrate from the first fluid through the at least one first semi-permeable membrane, through the gel matrix, through the at least one second semi-permeable membrane and into the second fluid, and determining clearance of the substance from the first fluid.
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An apparatus for analyzing the behaviour of molecules in simulated physiological environment, the apparatus comprising
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