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US 2020/0025656 A1Published application
Methods and devices for high throughput purification
AssigneesUniversity of Maryland, Baltimore, The Trustees of Princeton University
InventorsJoseph D'SILVA, Robert H. AUSTIN, Curt CIVIN, James C. STURM
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Abstract
Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.
Claims13
A method for transferring cells in a blood sample to a fluid medium, comprising flowing a blood sample and the fluid medium through separate inlets of a microfluidic device, wherein said device comprises:
- a) at least one microfluidic channel having at least two inlets and a plurality of outlets;
- and
- b) an array of obstacles arranged in rows and columns within the microfluidic channel, wherein the array of obstacles is configured to differentially separate cells based on size;
- wherein the blood sample is flowed at a flow rate of at least 100 ml/hour, and wherein passing the sample through the microfluidic channel transfers cells larger than a predetermined size to the fluid medium.
1 more element
Dependencies are inferred from the claim text.