Inhibition of respiratory complex iii by ligands that interact with a regulatory switch
AssigneeThe Regents of the University of California
InventorsMuhammad Hagras, Alexei Stuchebrukhov
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Abstract
The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.
Claims35
A method of inhibiting respiratory complex III in a cell, comprising:
- contacting the cell with a compound having a structure selected from the group consisting of:
- wherein
- each R1, R2, R3, R4, R5, and R6 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkylhydroxy, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C6-12 aryl, halogen, hydroxyl, oxide, —CN, —NH2, —NO2, and —C(O)—C1-6 alkyl, and —C(O)O−;
- the subscripts m and n are each independently integers from 0 to 5;
- the subscript p is an integer from 0 to 4;
- the subscripts q, u, and v are each independently integers from 0 to 2;
- and
- the subscript w is an integer from 0 to 3;
- such that the compound binds to respiratory complex III, thereby inhibiting respiratory complex III.
3-4. (canceled)
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34-35. (canceled)
37-38. (canceled)
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The method of claim 41, wherein the compound is selected from group consisting of
(canceled)
A method of treating cancer in a subject, the method comprising administering to the subject in need thereof, a therapeutically effective amount of a compound having a structure selected from the group consisting of:
- wherein
- each R1, R2, R3, R4, R5, and R6 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkylhydroxy, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C6-12 aryl, halogen, hydroxyl, oxide, —CN, —NH2, —NO2, and —C(O)—C1-6 alkyl, and —C(O)O−;
- the subscripts m and n are each independently integers from 0 to 5;
- the subscript p is an integer from 0 to 4;
- the subscripts q, u, and v are each independently integers from 0 to 2;
- and
- the subscript w is an integer from 0 to 3.
Dependencies are inferred from the claim text.