# US 2020/0022386 A1 · Method of preparation of cannabinoids containing beverages > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2020/0022386 A1 - Document ID: US20200022386A1 - Status: Published application - Kind: A1 - Application number: 16/514,724 - Filed: 2019-07-17 - Published: 2020-01-23 - Earliest claimed: 2018-07-17 - Assignees: Pharcon Corporation; RMW Pharma Consulting, Inc. - Applicants: Pharcon Inc.; RMW Pharma Consulting, Inc. - Inventors: Joseph Schwarz; Michael Weisspapir - Web page: https://patentgrep.com/patent/US20200022386A1 ## CPC - A23L 2/38: Other non-alcoholic beverages (drinks from legumes A23L11/60) - A23L 2/52: Adding ingredients (adding preservatives A23B70/10) - A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21) - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A23L 33/115: Fatty acids or derivatives thereof; Fats or oils - A23L 33/12: Fatty acids or derivatives thereof - A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)} - A61K 9/1075: {Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence)} - C12G 3/06: with flavouring ingredients - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C12G: WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES (beer C12C); PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H ## Abstract The present disclosure relates to a method of preparation of beverages, containing poorly water soluble cannabinoids, by two-stage dilution of the self-nanoemulsifying concentrate, and composition of the concentrate for preparation of such beverages. ## Claims ### Claim 1 A method for preparing an alcoholic or non-alcoholic carbonated or non-carbonated beverage comprising at least one cannabis component, wherein the method comprises the steps of: (a) diluting a SNEDS concentrate of at least one cannabis component with a liquid in ratio of liquid to concentrate from about 1:1 to about 100:1 by volume to form a pre-diluted mixture, and (b) combining the pre-diluted mixture with an amount of a beverage thus forming a cannabinoid composition. ### Claim 2 (depends on 1) The method of claim 1, wherein the cannabis component is selected from the group consisting of cannabinoids, cannabis extract, individual biologically active components of cannabis and mixture thereof. ### Claim 3 (depends on 1) The method of claim 1, wherein the liquid is a beverage, water or a water-containing liquid. ### Claim 4 A method for preparing an alcoholic or non-alcoholic carbonated or non-carbonated beverage comprising at least one cannabis component selected from the group consisting of cannabinoids, cannabis extract, individual biologically active components of cannabis and mixture thereof by consequent two-steps dilution of a self-nanoemulsifying concentrate, wherein the concentrate comprises at least one physiologically acceptable aromatic compound for solubilization of the cannabis components, and wherein the concentrate spontaneously forms oil-in-water nanoemulsion upon dilution. ### Claim 5 (depends on 4) The method of claim 4, wherein the concentrate is first diluted by addition of a beverage, water or a water-containing liquid to the concentrate in ratio of beverage, water or water-containing liquid to concentrate from about 1:1 to about 100:1 by volume to form a pre-diluted mixture, followed by further dilution of the pre-diluted mixture by addition of the pre-diluted mixture to a beverage, water or a water-containing liquid in a ratio of the pre-diluted mixture to the beverage, water or a water-containing liquid from about 1:5 to about 1:1000 by volume. ### Claim 6 (depends on 5) The method of claim 5, wherein the dilution are carried out at temperatures from about 0° C. to about 100° C. ### Claim 7 (depends on 4) The method of claim 4, wherein a portion of the beverage, water or a water-containing liquid used for first stage dilution is degassed and filtered through membrane filter with pore sizes from about 0.1 to about 5.0 mcm. ### Claim 8 (depends on 4) A method of claim 4, wherein: (a) the at least one cannabis component is completely dissolved in the concentrate; (b) the concentrate comprises at least one physiologically acceptable aromatic compound forming an oil phase wherein the at least one cannabis component remains completely dissolved in the oil phase after formation of the oil-in-water nanoemulsion; said aromatic compound comprises from about 10% to about 100% of the oil phase; (c) the concentrate comprises at least one physiologically acceptable surfactant or mixture of surfactants; and (d) the concentrate optionally comprises solubilized cannabis terpenes, physiologically acceptable essential oils or mixture thereof. ### Claim 9 (depends on 8) The concentrate of claim 8, wherein said physiologically acceptable aromatic compound is selected from the group consisting of liposoluble vitamins E, tocols, tocotrienols, tocopherols or tocopherol esters, anisole, anethole, esters of benzyl or phenethyl alcohol; esters of benzoic and salicylic acid. ### Claim 10 (depends on 8) The concentrate of claim 8, further optionally comprising a hydrophobic component selected from the group consisting of edible mono-, di-or triglycerides, acetylated mono- and diglycerides, fatty acids, fatty acids esters, aromatic and aliphatic esters, edible essential oils, and a mixture thereof. ### Claim 11 (depends on 10) The concentrate of claim 10, further optionally comprising at least one physiologically acceptable phospholipid, co-surfactant, water miscible co-solvent, solubilizer, flavor, flavor enhancers, antioxidant, preservative, colorant, sweetener and a mixture thereof. ### Claim 12 (depends on 5) A beverage prepared by dilution of the concentrate of claim 5 wherein the concentrate spontaneously forms a submicron oil-in-water emulsion. ### Claim 13 (depends on 12) The beverage of claim 12, wherein said oil-in-water emulsion comprises droplets with average size between about 5 nm to about 200 nm. ### Claim 14 (depends on 4) The self-nanoemulsifying concentrate of claim 4, wherein the concentrate comprises physiologically acceptable surfactant or mixture of surfactants, selected from the group of polyethoxylated tocopheryl succinate esters, polyethoxylated castor oil esters, polyethoxylated sorbitan esters, PEG esters of fatty acids, polyglyceryl fatty acid esters, fatty acid esters of saccharides, acyl glycosides, phospholipids, anionic surfactants and mixture thereof. ### Claim 15 (depends on 14) The concentrate of claim 14, wherein said phospholipids are selected from the group consisting of lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, lysophosphatides, phosphatidic acids and salts thereof, enzyme treated lecithins and phosphatidylglycerol derivatives.