Heated device for array synthesis
OwnerNeal Woodbury, Zhan-Gong Zhaoinventors
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Abstract
The manufacturing of molecular arrays often requires the coordination of various physical, chemical, and thermal parameters. Hence, the quality and homogeneity of many molecular arrays can be very dependent on the method of manufacturing. The instant disclosure provides a device that is configured to consistently yield peptide arrays of high quality. The device distributes optimum levels of heat and coupling solution during the chemical coupling and manufacturing of peptide array.
Claims21
A device for the manufacture of a molecular array, the device comprising:
- a) a heating component, whereby the heating component provides a level of thermal uniformity across a surface that varies by no more than 5° C. as measured from a center to an edge of the surface;
- b) a spinning component coupled to the heating component;
- whereby the spinning component distributes a continuous or a semi-continuous amount of a fluid comprising one or more molecular monomers, a coupling solution, or a wash solution to the surface,
- whereby the contemporaneous use of the heating component and the spinning component in the manufacture of the molecular array provides a homogeneous coupling of the one or more molecular monomers to at least 80% of the surface exposed to the monomer.
A device for the manufacture of a molecular array, the device comprising:
- a) a heating component;
- and
- b) a spinning component coupled to the heating component;
- whereby the spinning component distributes a continuous or a semi-continuous amount of a fluid comprising one or more molecular monomers, a coupling solution, or a wash solution to a molecular array surface.
A method for the manufacture of a molecular array, comprising:
- a) placing an array substrate having a surface on a heating component;
- and
- b) spinning said heating component and substrate such that a continuous or a semi-continuous amount of a fluid comprising one or more molecules, a coupling solution, or a wash solution is applied to the array substrate surface.
Dependencies are inferred from the claim text.