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US 2020/0010830 A1Published application
Methods and compositions related to increased viral production
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorRalph A Tripp
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions and methods for increasing virus production.
Claims26
A cell or cell line comprising decreased expression of one or more of the genes comprising BTN2A1, CNTD2, COQ9, EMX2, EP300, FGF2, GCGR, NAT9, NDUFA9, NEU2, PLA2G1B, PYCR1, RAD51AP1, SEC61G, STRADA, SVOPL, ZFYVE9, or ZNF205.
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A method of increasing viral production comprising infecting a cell or cell line with a virus;
- incubating the cell or cell line under conditions suitable for production of the virus by the cell, cells, or cell line;
- wherein the medium comprises an RNA polynucleotide that inhibits the expression of one or more cellular genes or wherein the cell or cell line comprises reduced expression of one or more cellular genes;
- wherein the one or more cellular genes are selected from the group comprising BTN2A1, CNTD2, COQ9, EMX2, EP300, FGF2, GCGR, NAT9, NDUFA9, NEU2, PLA2G1B, PYCR1, RAD51AP1, SEC61G, STRADA, SVOPL, ZFYVE9, or ZNF205.
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Dependencies are inferred from the claim text.