Synthesis of polyphosphorylated molecules from polyphosphates
AssigneeMassachusetts Institute of Technology
InventorsChristopher C. Cummins, Scott Shepard
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Abstract
Metaphosphate compounds can directly phosphorylate other compounds to provide easy synthetic access to phosphorylated compounds, including cyclic phosphate compounds.
Claims14
A method of polyphosphorylating a compound comprising contacting the compound with an activated polyphosphate, wherein the compound includes a nucleophilic group.
A compound comprising a triphosphorylated or tetraphosphorylated compound, wherein the triphosphorylated or tetraphosphorlyated compound includes a cyclic phosphate.
A compound comprising a trimetaphosphate 7-azabenzotriazole phosphoester, a trimetaphosphate benzotriazol-1-yl-oxy phosphoester or tetraphosphorylating agent anhydride [P4O11]2−.
A method of polyphosphorylating a compound comprising contacting monohydrogen tetrametaphosphate with a protein coupling agent to form an activated polyphosphate and contacting the activated polyphosphate with the compound.
Dependencies are inferred from the claim text.