Polymer-silica hybrid pdots and methods of use thereof
AssigneeUniversity of Washington
InventorsDaniel T. CHIU, Jiangbo YU, Yu RONG, Changfeng WU
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Abstract
The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
Claims47
An organic-inorganic hybrid polymer dot comprising:
- a semiconducting chromophoric polymer;
- and
- an inorganic network,
- wherein the semiconducting chromophoric polymer and the inorganic network form an organic-inorganic interpenetrated network.
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A method of making an organic-inorganic hybrid polymer dot, the method comprising:
- providing a solution, wherein the solution comprises a solvent, a semiconducting chromophoric polymer, and an organo-silane;
- and
- mixing the solution with an aqueous solution,
- wherein at least one of the solution or the aqueous solution comprises an organo-silane comprising X, and wherein X is a functional group suitable for bioconjugation.
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An organic-inorganic hybrid polymer dot comprising:
- a semiconducting chromophoric polymer comprising a plurality of units, M, selected from:
- wherein:
- RS is:
- RF is:
- A0, A4, A8, A12, A15, A18, are each independently CnH2n or CnH2n;
- A1, A2, A3, A5, A6, A7, A9, A10, A11, A13, A14, A16, A17, A19 are each independently CmH2m+1 or CmF2m+1;
- X1, X2, X3, X4 are each independently a functional group;
- n is not less than 1;
- and
- m is not less than 1;
- X, wherein X is a functional group suitable for bioconjugation;
- and
- an inorganic network that is covalently bonded to the semiconducting chromophoric polymer.
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Dependencies are inferred from the claim text.