Systems and methods for determining attributes of biological samples
AssigneeLiquid Biosciences, Inc.
InventorsPatrick Lilley, Beau Walker, Michael John Colbus
Life of this patent
Estimating the term…
Abstract
Systems and methods of determining pre-quantitation attributes of biological samples using post-quantitation attributes of those samples is disclosed. By altering a set of biological samples in a measurable way before running the set through an instrument (e.g., a mass spectrometer), a model can be developed that enables determination of the unknown pre-quantitation attributes in other biological samples as a function of post-quantitation attributes.
Claims20
A method of determining an unknown pre-quantitation attribute of a target biological sample using an electronic device, comprising the steps of:
- receiving, via the electronic device, a set of biological data pairs, each biological data pair corresponding to an altered biological sample and comprising a known pre-quantitation attribute and a set of post-quantitation attributes;
- computationally developing an at least one model, via the electronic device using the set of biological data pairs, describing a relationship between (1) a subset of post-quantitation attributes and (2) the known pre-quantitation attribute;
- and
- applying, via the electronic device, a set of target biological sample post-quantitation attributes to the at least one model to determine the unknown pre-quantitation attribute of the target biological sample.
A method of determining a quality of a target biological sample using an electronic device, comprising the steps of:
- receiving, via the electronic device, a set of biological data pairs, each biological data pair corresponding to an altered biological sample and comprising a known quality and a set of post-quantitation attributes;
- computationally developing an at least one model, via the electronic device using the set of biological data pairs, describing a relationship between (1) a subset of post-quantitation attributes and (2) the known quality;
- and
- applying, via the electronic device, a set of target biological sample post-quantitation attributes to the at least one model to determine the quality of the target biological sample.
A system for use with an instrument, where the system develops an at least one model to determine an unknown pre-quantitation attribute of a target biological sample, comprising:
- a computational modeling device communicatively coupled with the instrument, the instrument configured to analyze altered biological samples to produce sets of post-quantitation attributes corresponding to the altered biological samples;
- wherein each altered biological sample that has been analyzed by the instrument corresponds to a biological data pair, each biological data pair comprising a known pre-quantitation attribute and a set of post-quantitation attributes;
- wherein the device:
- receives sets of biological data pairs as input, and
- computationally develops an at least one model describing a relationship between (1) post-quantitation attributes and (2) the known pre-quantitation attribute, such that the at least one model can be applied to a set of target biological sample post-quantitation attributes to determine the unknown pre-quantitation attribute of the target biological sample.
Dependencies are inferred from the claim text.