Chimeric antigen receptor t cell therapy
AssigneeKite Pharma, Inc.
InventorsAdrian I. BOT, William Y. GO, Yizhou JIANG, John M. ROSSI, Xiaodong XUE
Life of this patent
Estimating the term…
Abstract
The disclosure relates to, in part, methods of CAR-T cancer treatment and methods of predicting clinical outcomes in response to those treatments. The methods comprise the use of baseline Sum of Product Diameters of Index Lesions and baseline number of lines of prior therapy as indicators.
Claims21
A method of predicting a response to CD19 CAR-T treatment in a subject having cancer, comprising measuring a baseline SPD in the subject, determining the SPD range, wherein a low SPD range indicates a likelihood of positive response to the CAR-T treatment.
A method of treating cancer in a subject in need thereof, comprising administering a therapeutically effective amount of a CD19 CAR-T treatment to a subject in which the baseline SPD value is in the SPD Quartiles 1 through 4.
A method of:
- predicting a likelihood of relapse after CD19 CAR-T treatment in a subject having cancer, comprising determining the number of lines of prior therapy in the subject, determining where the number falls within one of four ranges, whereby the higher the number of lines of prior therapy the higher likelihood of relapse after CD19 CAR-T treatment for the subject is predicted to be;
- or
- predicting the likelihood of ongoing response to CD19 CAR-T treatment in a subject having cancer, comprising measuring the baseline number of lines of prior therapy in the subject, determining where the number falls within one of four ranges, whereby the lower the range indicates the likelihood of ongoing response to CD19 CAR-T treatment.
(canceled)
A method of treating cancer in a subject in need thereof, comprising administering a therapeutically effective amount of a CD19 CAR-T treatment to a subject in which the number of lines of prior therapy in the subject is 1-2;
- 3;
- 4;
- or ≥5.
A method of predicting long-term response durability to treatment of cancer with anti-CD19 CAR-T cell treatment in a patient in need thereof, the method comprising assessing progression free survival at 3 months after a single dose of treatment, wherein achievement of complete or partial response at 3 months is predictive of long-term response durability in the patient.
Dependencies are inferred from the claim text.