Multiwell microelectrode array with optical stimulation

An electro-optical stimulation and recording system, comprising:

• a substrate;
• a plurality of wells coupled to the substrate;
• a plurality of electrode arrays, each of the electrode arrays being positioned at a base of one of the plurality of wells, wherein each respective electrode array comprises a plurality of electrodes, each individual electrode of the respective electrode array being configured to collect an electric signal associated with a respective portion of one of the plurality of wells,
• a plurality of light-emitting element sets, each of the plurality of light-emitting element sets corresponding to one of the plurality of wells and configured to deliver optical stimulation to at least a portion of one of the plurality of wells.