Hippo and dystrophin complex signaling in cardiomyocyte renewal
AssigneesBaylor College of Medicine, Texas Heart Institute
InventorsJames F. Martin, Yuka Morikawa, Todd Ryan Heallen, John Leach
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Abstract
Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.
Claims17
An isolated synthetic nucleic acid composition, comprising SEQ ID NO:11 and/or a derivative nucleic acid comprising at least 80% identity to SEQ ID NO:11, wherein the composition further comprises an antisense sequence of SEQ ID NO:11, wherein when the sequence and the antisense sequence are hybridized together to form a duplex structure, the sequence and the antisense sequence are separated by a loop structure.
Dependencies are inferred from the claim text.