Composition for cell regeneration comprising cells hypersecreting growth factors, and at least one of neural stem cells, neurons and gabaergic neurons
AssigneeKcellbio Banking Co., Ltd.
InventorsMi Sook CHANG, Ji Hye PARK
Life of this patent
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Abstract
A cell composition includes neural stem cells and neural stem cells derived from mesenchymal stem cells, and at least one selected from the group consisting of immature neural stem cells and mesenchymal stem cells. The number of the neural stem cells is at least 70% of the number of the cells included in the cell composition, and the total number of the cells of the immature neural stem cells and the mesenchymal stem cells is at most 30% of the number of the cells included in the cell composition. The cell composition has a very low probability of being developed into a cancer cell and thus can be used as a cell therapeutic.
Claims20
A cell composition comprising:
- neural stem cells;
- and
- neural stem cells derived from mesenchymal stem cells;
- and
- at least one selected from the group consisting of immature neural stem cells and mesenchymal stem cells;
- wherein the number of the neural stem cells is at least 70% of the number of the cells included in the cell composition, and the total number of the cells of the immature neural stem cells and the mesenchymal stem cells is at most 30% of the number of the cells included in the cell composition.
A neuron differentiated from a mesenchymal stem cell, wherein the neuron expresses at least one selected from the group consisting of Tuj1, MAP2, FoxG1, Nkx2.1, Pax6, Dlx2, Dlx5, Lhx6, GAD67, SCN5A, GFAP, S100β, Olig2, and NeuN.
A GABAergic neuron differentiated from a mesenchymal stem cell, wherein the GABAergic neuron expresses at least one selected from the group consisting of NKX2.1, LHX6, TuJ1, MAP2, MGE, Dlx2, Dlx5, GABRA1, GABRA2, GABRA5, CALB2, GAD65, GAD67, PSD95, NF-M, and SYP.
A composition for cell regeneration comprising:
- at least one selected from the group consisting of neural stem cells, neurons, and
- GABAergic neurons;
- and
- cells that hypersecrete a growth factor.
Dependencies are inferred from the claim text.