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US 2020/0002437 A1Published application
Anti-brdu antibodies and methods of use
AssigneeHoffmann-La Roche Inc.
InventorsUlrich Brinkmann, Guy Georges, Johannes Auer, Wilma Lau
Life of this patent
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Abstract
The invention provides anti-BRDU antibodies and methods of using the same.
Claims42
A humanized anti-BRDU antibody, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 01, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 04, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 06, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 08, wherein each HVR contains no more than one amino acid substitution.
3 more elements
2-4. (canceled)
A humanized anti-BRDU antibody, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 01, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 13, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 06, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 08, wherein each HVR contains no more than one amino acid substitution.
3 more elements
6-7. (canceled)
(canceled)
Use of an antibody comprising
- a) the light chain of a first antibody that specifically binds to a first antigen, and
- b) the heavy chain of the first antibody that specifically binds to the first antigen conjugated at its C-terminus to a scFv or a scFab derived from a second antibody that specifically binds to a second antigen,
- whereby either the first antibody or the second antibody is an anti-BRDU antibody,
- for the delivery of a BRDU-containing nucleic acid to a cell.
1 more element
24-25. (canceled)
(canceled)
Dependencies are inferred from the claim text.