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US 2020/0002401 A1Published application
Cd44 binding peptides
AssigneeExchange Imaging Technologies GmbH
InventorsCLAUDIA ARNTZ, WOLFGANG GREB
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Abstract
The present invention relates to a protein which binds to the domain encoded by exon 9 of human CD44 (CD44ex9), to fusion proteins and conjugates of said protein and especially to nanoparticles conjugated to said protein. The invention further relates to a method of production for the protein and the respective conjugated nanoparticles and the use of the protein of the invention for treatment and diagnosis of cancer diseases.
Claims18
1-24. (canceled)
A conjugate comprising:
- (a) protein binding to a polypeptide encoded by exon 9 of human CD44 (CD44ex9), said protein comprises or consists of
- (i) an amino acid sequence according SEQ ID No. 1,2,3, SEQ ID No. 39 to 50 and SEQ ID No. 52;
- (ii) an amino acid sequence with at least 90% identity to the amino acid sequence given in SEQ ID No. 1 to 5, SEQ ID No. 39 to 50 and SEQ ID No. 52;
- or
- (iii) an amino acid sequence with at least 97.5% identity to the amino acid sequence given in SEQ ID No. 4, and
- wherein said protein has a length of 100 amino acids or less, and
- (b) at least one of a heterologous protein, a heterologous polypeptide, or a compound conjugated, fused, or linked to the CD44ex9-binding protein.
4 more elements
Dependencies are inferred from the claim text.