Oxysterols and methods of use thereof
AssigneeSage Therapeutics, Inc.
InventorsFrancesco G. Salituro, Albert Jean Robichaud, Gabriel Martinez Botella, Boyd L. Harrison, Andrew Griffin, Daniel La
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Abstract
Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, and R6, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
Claims31
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is hydrogen or C1-C6 alkyl;
- each of R2 and R3 is independently hydrogen, C1-C6 alkyl, or carbocyclyl, or R2 and R3, together with the carbon atom to which they are attached, form a 3-8 membered ring;
- R6 is absent or hydrogen;
- R11a is hydrogen or C1-C6 alkyl and R11b is —OH or C1-C6 alkyl, or R11a and R11b are joined together to form oxo;
- and
- represents a single or double bond, wherein when one is a double bond, the other is a single bond;
- and when one of the is a double bond, R6 is absent.
16-17. (canceled)
19-23. (canceled)
A compound selected from the group consisting of:
A pharmaceutically acceptable salt of a compound selected from the group consisting of:
27-33. (canceled)
(canceled)
Dependencies are inferred from the claim text.