Back to results
US 2020/0002292 A1Published application
BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS
AssigneeKnopp Biosciences LLC
InventorsLynn RESNICK, George T. TOPALOV, Justin K. BELARDI, James S. HALE, Scott S. HARRIED, Charles A. FLENTGE, David A. MARESKA
Life of this patent
Estimating the term…
Abstract
Optionally substituted benzoimidazol-1,2-yl amides, such as compounds of Formula 1 or Formula 2, can be used to treat disorders associated with a Kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.
Claims9
1-21. (canceled)
A compound represented by a formula:
- wherein:
- D is cyclobutyl;
- A is C1-8 alkyl;
- X is H;
- Y is methyl(2,2,2-trifluoroethyl)amino;
- R1 is H, Cl, Br, CN, OCH3, CF3, —CO2CH2CH3, C1-4 alkyl, or C1-4 hydroxyalkyl;
- R2 is H, F, —CH2OH, —CO2Me, or —C(CH3)2OH;
- R3 is H;
- and
- R4 is H, —CH3, or —CF3.
7 more elements
A compound represented by a formula:
- wherein:
- D is cyclobutyl;
- A is C1-8 alkyl;
- X is CF3;
- Y is dimethylamino;
- R1 is H, Cl, Br, CN, OCH3, CF3, —CO2CH2CH3, C1-4 alkyl, or C1-4 hydroxyalkyl;
- R2 is H, F, —CH2OH, —CO2Me, or —C(CH3)2OH;
- R3 is H;
- and
- R4 is H, —CH3, or —CF3.
7 more elements
Dependencies are inferred from the claim text.