Pyrazole derivatives having activity against pain

A compound of Formula (I):

• wherein
• m is 0, 1, 2, 3 or 4;
• n is 1, 2, 3 or 4;
• X is —C(RxRx′)—, —C(O)— or —O—;
• Rc is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl and unsubstituted C2-6 alkynyl;
• R1 is selected from the group consisting of substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl and substituted or unsubstituted heterocyclyl;
• wherein the alkyl, alkenyl or alkynyl in R1, if substituted, is substituted with one or more substituent/s selected from the group consisting of —OR6, —C(O)R6, halogen, —CN, haloalkyl, haloalkoxy and —NR6R6′″;
• wherein the cycloalkyl aryl or heterocyclyl in R1, if substituted, is substituted with one or more substituent/s selected from the group consisting of halogen, —R6, —OR6, —NO2, —NR6R6′″, NR6C(O)R6′, —NR6S(O)2R6′, —NR6C(O)NR6′R6″, —SR6, —S(O)R6, S(O)2R6, —CN, haloalkyl, haloalkoxy, —C(O)OR6, —C(O)NR6R6′, —OCH2CH2OH, —NR6S(O)2NR6′R6″ and C(CH3)2OR6;
• wherein R6, R6′ and R6″ are independently selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl and unsubstituted C2-6 alkynyl;
• and R6′″ is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl and -Boc;
• R2 is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;
• wherein the aryl or heterocyclyl in R2, if substituted, is substituted with one or more substituent/s selected from the group consisting of halogen, —R7, —OR7, —NO2, —NR7R7′″, NR7C(O)R7′, —NR7S(O)2R7′, —S(O)2NR7R7′, —NR7C(O)NR7′R7″, —SR7, —S(O)R7, S(O)2R7, —CN, haloalkyl, haloalkoxy, —C(O)OR7, —C(O)NR7R7′, —OCH2CH2OH, —NR7S(O)2NR7′R7″, and C(CH3)2OR7;
• wherein R7, R7′ and R7′″ are independently selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl and unsubstituted C2-6 alkynyl;
• and wherein R7′″ is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl, unsubstituted heterocyclyl, and -Boc;
• R3 and R3′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl;
• wherein the alkyl, alkenyl or alkynyl in R3 or R3′, if substituted, is substituted with one or more substituent/s selected from the group consisting of —OR8, —C(O)R8, halogen, —CN, haloalkyl, haloalkoxy and —NR8R8′″;
• wherein R8 is selected from the group consisting of hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl and unsubstituted C2-8 alkynyl;
• and wherein R8′″ is selected from the group consisting of hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8 alkynyl and -Boc;
• R4 and R4′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl and substituted or unsubstituted C2-6 alkynyl;
• R5 and R5′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl and substituted or unsubstituted C2-6 alkynyl;
• Rx and Rx′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl and substituted or unsubstituted C2-6 alkynyl;
• wherein, the alkyl, alkenyl or alkynyl, other than those defined in R1, R3 or R3′, if substituted, is substituted with one or more substituent/s selected from the group consisting of —OR9, halogen, —CN, haloalkyl, haloalkoxy, unsubstituted heterocyclyl, —C(O)OR9, —C(O)NR9R9′″ and —NR9R9′″;
• wherein R9 is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, and unsubstituted C2-6 alkynyl;
• and wherein R9′″ is selected from the group consisting of hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8 alkynyl and -Boc;
• optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or as a mixture of at least two of stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof;
• with the following provisos applying:
• when X is —O—, then R1 is selected from substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;
• when X is —CH2—, then —[C(R4R4′)]m—R1 is not unsubstituted methyl;
• when X is —C(O)— and m is 0, then R2 is selected from substituted or unsubstituted monocyclic aryl and substituted or unsubstituted monocyclic aromatic heterocyclyl;
• and wherein the following compound is excluded from Formula (I):

A compound of Formula (I):

• wherein
• m is 0, 1, 2, 3 or 4;
• n is 1, 2, 3 or 4;
• X is —C(RxRx′)—, —C(O)— or —O—;
• Rc is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl and unsubstituted C2-6 alkynyl;
• R1 is selected from the group consisting of substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;
• wherein the alkyl, alkenyl or alkynyl in R1, if substituted, is substituted with one or more substituent/s selected from the group consisting of —OR6, —C(O)R6, halogen, —CN, haloalkyl, haloalkoxy and —NR6R6′″;
• wherein the aryl or heterocyclyl in R1, if substituted, is substituted with one or more substituent/s selected from the group consisting of halogen, —R6, —OR6, —NO2, —NR6R6′″, NR6C(O)R6′, —NR6S(O)2R6′, —NR6C(O)NR6′R6″, —SR6, —S(O)R6, S(O)2R6, —CN, haloalkyl, haloalkoxy, —C(O)OR6, —C(O)NR6R6′, —OCH2CH2OH, —NR6S(O)2NR6′R6″ and C(CH3)2OR6;
• wherein R6, R6′ and R6′″ are independently selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl and unsubstituted C2-6 alkynyl;
• and R6′″ is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl and -Boc;
• R2 is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;
• wherein the aryl or heterocyclyl in R2, if substituted, is substituted with one or more substituent/s selected from the group consisting of halogen, —R7, —OR7, —NO2, —NR7R7′″, NR7C(O)R7′, —NR7S(O)2R7′, —S(O)2NR7R7′, —NR7C(O)NR7′R7″, —SR7, —S(O)R7, S(O)2R7, —CN, haloalkyl, haloalkoxy, —C(O)OR7, —C(O)NR7R7′, —OCH2CH2OH, —NR7S(O)2NR7′R7″, and C(CH3)2OR7;
• wherein R7, R7′ and R7′″ are independently selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl and unsubstituted C2-6 alkynyl;
• and wherein R7′″ is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl and -Boc;
• R3 and R3′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl;
• wherein the alkyl, alkenyl or alkynyl in R3 or R3′, if substituted, is substituted with one or more substituent/s selected from the group consisting of —OR8, —C(O)R8, halogen, —CN, haloalkyl, haloalkoxy and —NR8R8′″;
• wherein R8 is selected from the group consisting of hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl and unsubstituted C2-8 alkynyl;
• and wherein R8′″ is selected from the group consisting of hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8 alkynyl and -Boc;
• R4 and R4′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl and substituted or unsubstituted C2-6 alkynyl;
• R5 and R5′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl and substituted or unsubstituted C2-6 alkynyl;
• Rx and Rx′ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl and substituted or unsubstituted C2-6 alkynyl;
• wherein, the alkyl, alkenyl or alkynyl, other than those defined in R1, R3 or R3′, if substituted, is substituted with one or more substituent/s selected from the group consisting of —OR9, halogen, —CN, haloalkyl, haloalkoxy and —NR9R9′″;
• wherein R9 is selected from the group consisting of hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, and unsubstituted C2-6 alkynyl;
• and wherein R9′″ is selected from the group consisting of hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8 alkynyl and -Boc;
• optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or as a mixture of at least two stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof;
• with the following provisos applying:
• when X is —O—, then R1 is selected from substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;
• when X is —C(O)— and m is 0, then R2 is selected from substituted or unsubstituted monocyclic aryl and substituted or unsubstituted monocyclic aromatic heterocyclyl;
• and wherein the following compound excluded from Formula (I):