Method for the one-pot production of organo-iodinated compounds

A process for preparing an organo-iodized compound, the process comprising the following steps:

• a) acylating 2,4,6-triiodo-5-aminoisophthalic acid having a chemical structure corresponding to formula (A):
• with a compound having a chemical structure corresponding to formula (II):
• R2—C(O)Cl (II)
• to form an intermediate compound Y;
• b) chlorinating the intermediate compound Y to form the organo-iodized compound, which has a chemical structure corresponding to formula (I):
• wherein:
• R1 is H or a methyl group;
• and
• R2 is selected from the group consisting of:
• (C1-C20)alkyl, linear or branched;
• (C1-C20)alkenyl, linear or branched;
• (C1-C20)alkynyl, linear or branched;
• (C3-C10)cycloalkyl;
• (C6-C10)aryl;
• a heterocyclyl comprising 3 to 10 atoms;
• and
• a heteroaryl comprising 6 to 10 atoms;
• wherein:
• said alkyl, alkenyl and/or alkynyl groups optionally being substituted with one or more substituent(s) selected from the group constituted by atoms of halogen, oxygen and nitrogen;
• said alkyl, alkenyl and/or alkynyl groups optionally being interrupted by one or more group(s) selected from the group constituted by —O—, —C(O)—O— and —O—C(O)—;
• and
• said cycloalkyl, heterocyclyl, aryl and/or heteroaryl groups optionally being substituted with one or more substituent(s) selected from the group constituted by (C1-C20)alkyl, which may be linear or branched, and atoms of halogen, oxygen and nitrogen;
• wherein the steps a) and b) are performed without isolating the intermediate compound Y.

A compound having a chemical structure corresponding to formula (Y1):

• wherein:
• R1 is a methyl group;
• and
• R2 is selected from the group consisting of:
• (C1-C20)alkyl, linear or branched;
• (C1-C20)alkenyl, linear or branched;
• (C1-C20)alkynyl, linear or branched;
• (C3-C10)cycloalkyl;
• (C6-C10)aryl;
• a heterocyclyl comprising 3 to 10 atoms;
• and
• a heteroaryl comprising 6 to 10 atoms;
• wherein:
• said alkyl, alkenyl and/or alkynyl groups optionally being substituted with one or more substituent(s) selected from the group constituted by atoms of halogen, oxygen and nitrogen;
• said alkyl, alkenyl and/or alkynyl groups optionally being interrupted by one or more group(s) selected from the group constituted by —O—, C(O)—O— and —O—C(O)—;
• and
• said cycloalkyl, heterocyclyl, aryl and/or heteroaryl groups optionally being substituted with one or more substituent(s) selected from the group constituted by (C1-C20)alkyl, which may be linear or branched, and atoms of halogen, oxygen and nitrogen;
• and
• wherein R2 is not