Stable dry powders and emulsions containing probiotics
AssigneeVirun, Inc.
InventorPhilip J. Bromley
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Abstract
Compositions and methods for mucosal delivery of agents are provided. The emulsion compositions are intended for administration to a mucosal surface, such as oral, gastrointestinal and nasal mucosa. The emulsion compositions provided contain one or more mucoadhesive proteins and an agent to be delivered. Methods for delivery of agents using the compositions provided herein are also provided.
Claims34
A powder composition, comprising, by weight % of the composition:
- 5%-25% probiotic;
- and
- 5%-25% mucoadhesive protein,
- wherein:
- the total of probiotic and mucoadhesive protein is 20%-35%;
- 30%-50% ingestible oil;
- 5%-15% surfactant other than a vitamin E derivative;
- 10%-20% binder;
- and
- 4%-12% stabilizer.
A powder composition, comprising a probiotic, and a mucoadhesive protein, wherein:
- the total amount of the probiotic and mucoadhesive protein is up to at or about 15-35%, wherein the ratio thereof is between 1:5 and 5:1;
- the powder contains at least 5% by weight of probiotic;
- and
- the probiotic and mucoadhesive protein are associated via physical or chemical bonds with probiotic surface proteins.
A powder composition, comprising a probiotic and a mucoadhesive protein, wherein:
- the amount of sucrose fatty acid ester (SFAE) surfactant is 5%-15%, by weight;
- the amount of dextrin or maltodextrin is 5%-20%, by weight;
- the amount of probiotic is 5%-20%, by weight;
- the amount of mucoadhesive protein is 5%-20%, by weight;
- and
- the amount of MCT oil is 30%-50%, by weight.
The powder composition of claim 10, wherein:
- the amount of probiotic is 8%-15%, by weight;
- and
- the amount of mucoadhesive protein is 10%-17%, by weight.
An emulsion composition, comprising a polar phase and an oil phase, wherein:
- the polar phase contains, by weight:
- 50%-65% polar protic solvent;
- 1%-5% sucrose fatty acid ester (SFAE) surfactants;
- 0%-5% cosolvent;
- and
- 5%-10% dextrin or maltodextrin;
- and
- the oil phase contains, by weight:
- 1%-15% probiotic;
- 1%-15% mucoadhesive protein;
- and
- 10%-20% MCT oil.
An emulsion composition, comprising:
- a) a mucoadhesive protein associated with a probiotic, wherein:
- the mucoadhesive protein is present at a concentration of about or at 1%, by weight, up to about or at 10% of the total weight of the composition;
- the mucoadhesive protein is selected from among the family of transferrins and the family of mucin proteins;
- the probiotic is present at a concentration of about or at 1% to about or at 10%, by weight of the composition;
- the total concentration of mucoadhesive protein and probiotic is from about or at 2% to about or at 20%, by weight;
- the mucoadhesive protein is associated with the proteins on the probiotic bacterial surface via a chemical and/or physical bond;
- and
- b) a polar protic solvent in an amount between about or at 40% to 80%, by weight, of the composition;
- c) a consumable oil, in an amount between about or at 10%-20%, by weight, whereby the composition is formulated as an emulsion, wherein the composition does not include a PEG-derivative of vitamin E;
- and
- d) a surface active agent, other than a polyalkylene derivative of vitamin E.
Dependencies are inferred from the claim text.