US 2019/0390252 A1 · SYSTEMS AND METHODS FOR PRE-ANALYTICAL SUBSTRATE PROCESSING

Abstract

Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.

Claims24

Dependent claims

A method of processing a biological sample for a biological assay, comprising (a) contacting the biological sample with a contact medium comprising a particulate substance and pressurized air under conditions sufficient to effectuate at least partial transfer of a component in the biological sample to the contact medium;

and (b) removing the contact medium from the biological sample.

A bioanalytical system comprising (a) a first component for contacting a biological sample or a region therein with a contact medium comprising a particulate substance and pressurized air under conditions sufficient to effectuate at least a partial transfer of a component in the biological sample to the contact medium;

(b) a second component for removing the contact medium from the biological sample;
and (c) optionally a third component for analyzing the component in the contact medium or the processed biological sample or both the contact medium and the processed biological sample.

Dependencies are inferred from the claim text.

Facts

Application

16/449,075Filed 21 Jun 2019

Priority

21 Jun 2018

Published

26 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C12Q 1/686
Nucleic acid amplification reactions: polymerase chain reaction [PCR]
C12Q 1/6806
Involving nucleic acids: preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/6809
Involving nucleic acids: methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6813
Involving nucleic acids: hybridisation assays

Systems and methods for pre-analytical substrate processing

Life of this patent

Systems and methods for pre-analytical substrate processing

Life of this patent

Abstract

Claims24