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US 2019/0390176 A1Published application
Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMark A. Kay, Nicole K. Paulk
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Abstract
The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human muscle tissue or cells as compared non-variant parent capsid polypeptides.
Claims15
-15. (canceled)
An adeno-associated virus (AAV) vector comprising a nucleic acid sequence encoding a variant AAV capsid polypeptide, wherein said variant AAV capsid polypeptide exhibits increased transduction or tropism in human muscle tissue or cells as compared to a non-variant parent capsid polypeptide.
-39. (canceled)
Dependencies are inferred from the claim text.