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US 2019/0388380 A1Published application
Fumagillol type compounds and methods of making and using same
AssigneeZafgen, Inc.
InventorsRobert Zahler, James E. Vath
Life of this patent
Estimating the term…
Abstract
The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
Claims18
A compound represented by:
- wherein
- R1 is H or C1-3 alkyl;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
A compound represented by:
- wherein
- R2 is selected from the group consisting of H, hydroxyl, and isopropyl (optionally substituted with a hydroxyl);
- R3 is selected from the group consisting of H, and hydroxyl;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
1 more element
A compound represented by:
- wherein
- R′ is methyl;
- R″ is H or methyl;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
1 more element
A compound represented by:
- wherein
- R4 and R5 are each methyl;
- or
- R4 and R5, together with the nitrogen to which they are attached, form a 4-5 membered ring optionally substituted by one or two substituents independently selected from the group consisting of methyl and hydroxyl;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
2 more elements
A compound represented by:
- wherein
- n is 1 or 2;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
A compound selected from the group represented by:
- or a pharmaceutically acceptable salt or stereoisomer thereof.
A compound selected from the group consisting of:
- and a pharmaceutically acceptable salt or stereoisomer thereof.
Dependencies are inferred from the claim text.