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US 2019/0382771 A1Published application
ASYMMETRIC siRNA FOR INHIBITING EXPRESSION OF MALE PATTERN HAIR LOSS TARGET GENE
AssigneeOliX Pharmaceuticals, Inc.
InventorsSun Woo HONG, Jihye HWANG
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Abstract
The present invention relates to an asymmetric siRNA which inhibits an expression of male pattern hair loss target genes and a use thereof and, more particularly, to an asymmetric siRNA which inhibits an expression of 3-oxo-5-alpha-steroid-4-dehydrogenase 1 (SRD5A1) gene, 3-oxo-5-alpha-steroid-4-dehydrogenase 2 (SRD5A2) gene or androgen receptor (AR) gene, and a composition for prevention or treatment of hair loss comprising the asymmetric siRNA.
Claims11
siRNA specifically binding to mRNA of a 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)-encoding gene having SEQ ID NOs:
- 669, 670 or 671, mRNA of a 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)-encoding gene having SEQ ID NO:
- 672, or mRNA of an androgen receptor (AR)-encoding gene having SEQ ID NO:
- 673 and comprising a sense strand having a length of 15 nt to 17 nt and an antisense strand complementary to the sense strand and having a length of 19 nt or more,
- wherein a 3′-terminus of the sense strand and a 5′-terminus of the antisense strand form a blunt end.
1 more element
Dependencies are inferred from the claim text.