Malonyl-coenzyme a mimics as fatty acid synthase inhibitors and methods of use
AssigneePurdue Research Foundation
InventorsJeremy R. Lohman, Lee M. Stunkard
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Abstract
The present disclosure generally relates to novel compounds as a fatty acid synthase inhibitor useful for the treatment of infection diseases, cancers, or metabolic diseases that malfunction of fatty acid synthase is involved. In particular this present invention directs to malonyl-coenzyme A (CoA) mimetics and methods of use thereof. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using compounds disclosed herein.
Claims20
A compound having a formula
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein
- X is co-enzyme A (CoA),
- Y is methylene (—CH2—), S, SO, NR, NH, or O;
- Z is N+, S or SO;
- and
- R1 is hydrogen, an alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyloalkyl, cycloalkenyl, heterocycloakenyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, or arylalkenyl.
A method for treating a disease mediated by fatty acid synthase malfunction, such as infection diseases, cancers, metabolic diseases, inflammation, and immunological disorders, comprising the step of administering a therapeutically effective amount of one or more compounds of formula (I) or a pharmaceutically acceptable salt thereof, together with one or more carriers, diluents, or excipients, to a patient in need of relief from said disease,
- wherein
- X is co-enzyme A (CoA),
- Y is methylene (—CH2—), S, SO, NR, NH, or O;
- Z is N+, S or SO;
- and
- R1 is hydrogen, an alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyloalkyl, cycloalkenyl, heterocycloakenyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, or arylalkenyl.
Dependencies are inferred from the claim text.