# US 2019/0375759 A1 · Pyrazole acc inhibitors and uses thereof

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- Number: US 2019/0375759 A1
- Document ID: US20190375759A1
- Status: Published application
- Kind: A1
- Application number: 16/239,360
- Filed: 2019-01-03
- Published: 2019-12-12
- Earliest claimed: 2015-11-25
- Assignees: Gilead Apollo, LLC
- Applicants: Gilead Apollo, LLC
- Inventors: Shomir Ghosh; Jeremy Robert Greenwood; Geraldine C. Harriman; Silvana Marcel Leit de Moradei
- Web page: https://patentgrep.com/patent/US20190375759A1

## CPC

- C07D 495/04: Ortho-condensed systems
- A01N 43/90: having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61P 33/00: Antiparasitic agents
- C12N 9/93: {Ligases (6)}
- C12Y 604/01002: Acetyl-CoA carboxylase (6.4.1.2)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Y: ENZYMES

## Abstract

The present invention provides pyrazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

## Claims

### Claim at position 1

-26. (canceled)

### Claim 27

A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R1 is —CH3, —CHCF2, or —CF3;
R2 is
R3 is
R4 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, tertiary butyl, —CH2CH2OH, —CH2CCH, —CH2CH2CCH, —CH2CHCH2, —CH2CHCH(CH3)2, —CH2CN, —CH2CH2CN, —CH2COCH3, —CH2— cyclopropyl, —CH2CH2SCH3, —CH2CH2OCH3, —CH2CH2COOCH3, —CH2COOCH3, —COOCH3, —CH2CH2SO2CH3, —CH2CONH2,
X is H, F, Cl, Br, CN, CF3, methyl, ethyl, isopropyl, cyclopropyl, —SO2Me, —OCF2H, —CF2H, —OCF3, or —OCF2H;
Y is optionally substituted alkyl, cyanomethyl, cyanoethyl, or methoxyethyl;
T is independently H, F, Cl, or methyl;
each A is independently H, CH3, CH2CH3, CHCF3, CH2CF2H, propyl, isopropyl, butyl, cyclopropyl, tertiary butyl, isobutyl, neopentyl, or cyanoethyl; and
L1 is —CH(CH3), —C(CH3)2, or —CH2.