Modified surfaces for attachment of biological materials
AssigneeNortheastern University
InventorsDANIEL M. STOREY, TERRENCE S. MCGRATH, ALEXANDER B. REISING
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Abstract
The invention relates to bioactive surface coatings deposited on selected substrates. Surface nanostructured film coatings deposited on most metal or nonmetal substrates to provide surfaces can be engineered to promote enhanced tissue/cell adhesion. Attached cells, including osteoblasts, fibroblasts and endothelial cells, retain viability and will readily differentiate and proliferate under appropriate conditions. Fibroblasts and endothelial cells exhibit good attachment and growth on most coated substrates, except on nano surfaced structured silicone.
Claims22
An article comprising:
- a substrate surface;
- and
- a nanostructure disposed on the substrate surface via ion plasma deposition (IPD), wherein the nanostructure comprises particles embedded in the substrate surface, wherein the nanostructure substrate surface enhances osteoblast proliferation compared to an uncoated substrate.
An article comprising:
- a polymer substrate surface;
- and
- a nanostructure disposed on the substrate surface via ion plasma deposition (“IPD”), wherein the nanostructure comprises:
- an adhesive film having a first density of first particles;
- and
- a second film on top of the adhesive film, the second film having a second density of second particles, more than the first density of first particles,
- wherein the nanostructured substrate surface enhances osteoblast proliferation compared to an uncoated substrate.
A method of manufacturing an article comprising the steps of:
- (a) providing a polymer substrate surface;
- and
- (b) using ion plasma deposition to deposit a nanostructure on the substrate surface wherein the nanostructured substrate surface enhances osteoblast proliferation compared to an uncoated substrate.
An article comprising:
- a polymer substrate surface;
- and
- a nanostructure disposed on the substrate surface, wherein the nanostructure comprises particles embedded in the substrate surface, wherein the article is formed by the method of:
- using ion plasma deposition to deposit an adhesive film having a first density of first particles;
- using ion plasma deposition to deposit a second film on top of the adhesive film, the second film having a second density of second particles, more than the first density of first particles,
- such that the nanostructured substrate surface enhances osteoblast proliferation compared to an uncoated substrate.
Dependencies are inferred from the claim text.