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US 2019/0374663 A1Published application
Radiopharmaceutical products
AssigneeGe Healthcare Limited
InventorStig HEMSTAD
Life of this patent
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Abstract
The present invention relates to improved radiopharmaceutical compositions in sealed containers, where the container closure has an ETFE (ethylene-tetrafluoroethylene copolymer) coating. Also disclosed are kits for radiopharmaceutical preparation using the sealed containers, as well as methods of preparation of radiopharmaceuticals using the sealed containers.
Claims12
1-28. (canceled)
A method for imaging, which comprises
- (i) reaction of a synthetic ligand and a radioisotope composition, wherein the synthetic ligand comprises one or more phosphine, thiol or isonitrile metal-binding groups,
- the synthetic ligand composition comprising:
- (a) a synthetic ligand precursor,
- (b) an optional radioprotectant selected from ascorbic acid or a salt thereof with a biocompatible cation;
- (c) a biocompatible reductant that comprises stannous ion;
- and
- (d) an effective amount of a pH-adjusting agent that is sodium
- bicarbonate, sodium hydrogen carbonate, or a combination thereof;
- and
- the radioisotope composition comprising radioisotope capable of reacting with the synthetic ligand;
- and
- (ii) puncturing a pre-treated closure of a container that contains the product of the reaction in step (i) with a hypodermic needle while maintaining sealed integrity, the pre-treated closure comprising a chlorinated butyl rubber body which is coated with ethylene-tetrafluoroethylene copolymer (ETFE) on one or more of its surface(s) which are in contact with the container contents.
9 more elements
Dependencies are inferred from the claim text.