Materials and methods for treating cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsEvanthia GALANIS, S. Keith ANDERSON, Cheyne B. KUROKAWA, Ianko D. IANKOV
Life of this patent
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Abstract
This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of UFM1 activity or expression and/or an inhibitor of UFL1 activity or expression to reduce a cancer cell's ability to carry out a DDR, thereby increasing the sensitivity of cancer cells to treatment with a DNA damaging therapy such as radiation or chemotherapy, are provided.
Claims22
A method for treating cancer in a mammal, wherein said method comprises:
- (a) identifying said mammal as having cancer cells that have a virotherapy permissive interferon (IFN)-stimulated gene (ISG) signature, wherein said ISG signature comprises at least 6 ISGs selected from the group consisting of HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, IFI27, IFI35, IFI6, IFIT1, IFIT3, IRF1, IRF2, IRF9, ISG15, MX1, MX2, OAS1, OAS2, OAS3, OASL, SOCS1, and STAT2;
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- (b) administering an oncolytic virus to said mammal under conditions wherein the number of cancer cells within said mammal is reduced.
11-28. (canceled)
A method for treating cancer in a mammal, wherein said method comprises:
- (a) identifying said mammal as having cancer cells that are responsive to treatment with one or more oncolytic viruses, and
- (b) administering an oncolytic virus to said mammal under conditions wherein the number of cancer cells within said mammal is reduced.
39-92. (canceled)
Dependencies are inferred from the claim text.