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US 2019/0359587 A1Published application
Heterocyclic amide compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsTakaharu HIRAYAMA, Yasuhiro HIRATA, Yusuke TOMINARI, Naoki IWAMURA, Yusuke SASAKI, Moriteru ASANO, Terufumi TAKAGI, Masanori OKANIWA, Masato YOSHIDA, Shinichi IMAMURA
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Abstract
Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
Claims9
A compound represented by the following formula (I):
- wherein a group represented by
- is an optionally substituted aromatic ring group;
- R1 is a hydrogen atom, a halogen atom, a cyano group, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted amino group, or an optionally substituted hydroxy group;
- X1 is CR2 or a nitrogen atom;
- X2 is CR3 or a nitrogen atom;
- R2 and R3 are each independently a hydrogen atom, a halogen atom, or an optionally substituted alkyl group;
- X3 is CR4R5 or NR6, X4 is CR7R8, X5 is CR9R10 or an oxygen atom;
- R4 is a hydrogen atom, a cyano group, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- R5 is a cyano group, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- R4 and R5 are optionally bonded to each other to form, together with the adjacent carbon atom, an optionally further substituted ring;
- and
- R6, R7, R8, R9, and R10 are each independently a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group,
- or a salt thereof.
10 more elements
Dependencies are inferred from the claim text.