Back to results
US 2019/0358336 A1Published application
Cell internalizing compounds
AssigneeSorrento Therapeutics, Inc.
InventorsYanwen Fu, Gunnar F. Kaufmann, Heehyoung Lee, Tong Zhu, Henry Hongjun Ji
Life of this patent
Estimating the term…
Abstract
Provided herein are cell penetrating compounds having the Formula I: where, generally, each T is a thiol reactive group (e.g., a phosphorothioate), each L is a linker (e.g., a linear alkyl), and Y is a biologic (e.g., an antibody). Also provided are pharmaceutical compositions including the cell penetrating compounds, and methods of delivering the compound into a cell.
Claims22
A compound having the Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- each T is selected from a thiol reactive group, phosphorothioate, a thiophospho amino acid and maleimide;
- each L is a linker group;
- Y is a protein, an antibody, a peptide, or a nucleic acid;
- n is an integer from 1 to 50;
- and
- m is 0, 1, or 2.
4 more elements
2-12. (canceled)
A compound having the Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- each R is CH3 or H;
- each L is a linker;
- Y is a protein, an antibody, a peptide, or a nucleic acid;
- and
- n is an integer from 5 to 25.
3 more elements
23-39. (canceled)
A compound having a formula selected from Formula III, Formula IV, and Formula V:
- or a pharmaceutically acceptable salt thereof, wherein:
- L is a linker;
- m, where applicable, is an integer from 1 to 3;
- n is an integer from 5 to 25;
- Y is a protein, an antibody, a peptide, or a nucleic acid;
- and
- each R, where applicable, is independently selected from:
4 more elements
Dependencies are inferred from the claim text.