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US 2019/0353576 A1Published application
Cell analysis by mass cytometry
AssigneeFluidigm Canada Inc.
InventorVladimir Baranov
Life of this patent
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Abstract
A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
Claims21
(canceled)
A method of analysis comprising:
- interrogating, using at least one interrogator, a group of cells;
- identifying, using the at least one interrogator, the location of one or more candidate cells comprising at least one property of interest;
- and
- performing elemental analysis of the one or more candidate cells within the group of cells.
1 more element
A method of analysis, comprising:
- labeling a group of cells with more than one distinct element tag Tn to form a labeled group of cells;
- interrogating the labeled group of cells to identify a candidate cell or cells comprising at least one property of interest, such that the integrity of the at least one property of interest is maintained for subsequent interrogation;
- and
- identifying the location of the candidate cell or cells within the group of cells.
1 more element
A system, comprising:
- at least one interrogator configured to identify the location of a candidate cell by at least one property of interest, wherein each candidate cell is labeled with elemental tags;
- a data source formatted to record the location of the candidate cell for elemental analysis;
- and
- a detector configured to detect the elemental tags associated with the candidate cell.
1 more element
Dependencies are inferred from the claim text.