Modulation of ischemic cell bioenergetics
AssigneeEast Carolina University
InventorsJoseph Matthew McClung, Terence Ryan
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Abstract
Methods of treating ischemia by modulating ischemic cell bioenergetics are described. For example, the methods include the administration of small molecule, polypeptide, and/or genetic agents that modulate oxidative metabolism and/or glycolytic metabolism in ischemic cells, such as ischemic muscle cells. In some embodiments, the agent is adapted to deliver Cox6a2 or PFKFB3 to the cell. Also described are related pharmaceutical compositions and kits for the treatment of ischemia and ischemic injury related to, for instance, such as peripheral arterial disease, stroke, myocardial infarction, and diabetes.
Claims24
A method of treating ischemia in a subject, the method comprising:
- administering to the subject a composition comprising an agent adapted to modulate oxidative and/or glycolytic metabolism in ischemic cells in the subject;
- and
- treating at least one symptom associated with the ischemia in the subject.
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A method of classifying a subject having peripheral arterial disease (PAD) as unlikely to respond to an endovascular therapeutic intervention, a revascularization therapeutic intervention and/or a therapeutic intervention comprising physical activity, the method comprising:
- providing a sample from a subject having PAD, wherein the sample comprises myofibers from skeletal muscle;
- measuring mitochondrial function in the sample;
- and
- classifying the subject as being unlikely to respond to an endovascular therapeutic intervention, a revascularization therapeutic intervention and/or a therapeutic intervention comprising physical activity based on mitochondrial function.
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Dependencies are inferred from the claim text.