Targeted anticoagulant
AssigneeNorthwestern University
InventorsGuillermo A. Ameer, Yunxiao Zhu
Life of this patent
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Abstract
Provided herein is technology relating to anticoagulant therapies and particularly, but not exclusively, to anticoagulant compositions for localized and targeted administration and related methods and kits for treatment of a subject with a localized and targeted anticoagulant therapy.
Claims51
A composition for reducing coagulation of blood, the composition comprising:
- a) an anticoagulant;
- and
- b) a fibrin-binding peptide covalently linked to the anticoagulant.
A system for reducing coagulation of blood, said system comprising a composition comprising:
- a) an anticoagulant;
- and
- b) a fibrin-binding peptide covalently linked to the anticoagulant.
A method for treating a subject in need of anticoagulation therapy, the method comprising administering to the subject a composition comprising a fibrin-binding peptide covalently linked to an anticoagulant.
A method for producing a fibrin-binding peptide covalently linked to an anticoagulant, the method comprising:
- a) activating a carboxyl group on an anticoagulant;
- b) covalently linking a linker to the activated carboxyl group;
- and
- c) covalently linking a fibrin-binding peptide to the linker.
The method of claim 33 wherein the fibrin-binding peptide is SREKA (SEQ ID NO:
- 2);
- CKEKA (SEQ ID NO:
- 3);
- CRDKA (SEQ ID NO:
- 4);
- CRERA (SEQ ID NO:
- 5);
- CREKV (SEQ ID NO:
- 6);
- SKEKA (SEQ ID NO:
- 7);
- SRDKA (SEQ ID NO:
- 8);
- SRERA (SEQ ID NO:
- 9);
- SREKV (SEQ ID NO:
- 10);
- CKDKA (SEQ ID NO:
- 11);
- CKERA (SEQ ID NO:
- 12);
- CKEKV (SEQ ID NO:
- 13);
- CRDRA (SEQ ID NO:
- 14);
- CRDKV (SEQ ID NO:
- 15);
- or CRERV (SEQ ID NO:
- 16).
A reaction mixture comprising an anticoagulant and a linker.
Dependencies are inferred from the claim text.