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US 2019/0345099 A1Published application
Nitric oxide donors
AssigneeMedChem Partners, LLC
InventorsSteven RIESINGER, Tsvetelina LAZAROVA, Zinadia RIBKOVSKAIA
Life of this patent
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Abstract
The present invention provides, in part a novel class of nonoate compounds which exhibit nitric oxide releasing activity and their pharmaceutically acceptable salts, esters and prodrugs. The compounds release nitric oxide upon activation by contact with plasma. The present invention also relates to the use of the disclosed compounds to deliver nitric oxide to treat disorders arising from nitric oxide dysregulation.
Claims17
-55. (canceled)
A composition comprising a compound represented by the Formula I:
- or a pharmaceutically acceptable salt, ester or prodrug thereof, where:
- X is CH2 or CHCH3, m is 0, 1, 2 or 3 and n is 0 or 1, provided that when m is 0 n is 0;
- R is alkyl, preferably having from 1 to 6 carbon atoms;
- R1 is alkyl, preferably having from 1 to 6 carbon atoms;
- or R and R1 taken together are carbon atoms to form a 5-7 member heterocyclic ring, said 5-7 member heterocyclic ring being optionally substituted with —CH2OH;
- A is a negative charge with a Na+ counterion, —B(OR2)(OR3), —(Y)p—C(═O)—R4,
- SOqZ, 1,3-dioxoisoindolin-2-yl, heterocycloalkyl, or a lipid, where
- Y is —CH2— and p is 0 or 1;
- q is 0, 1 or 2;
- R2 and R3 are the same or different and are alkyl, preferably having from 1 to 6 carbon atoms or aryl, optionally substituted with —OH;
- R4 is alkyl (optionally substituted with —NH2), alkenyl, heteroalkyl (optionally substituted
- with one or more moieties independently selected from oxo, halo and aryl, N-alkyl, N-aryl, O-alkyl or O-aryl;
- and
- Z is alkyl, aryl, N-alkyl, N-aryl, O-alkyl or O-aryl.
11 more elements
A composition comprising a compound selected from:
- or a pharmaceutically acceptable salt, ester or prodrug thereof.
Dependencies are inferred from the claim text.