Materials and methods for controlling regulation in biosynthesis in species of the genera ralstonia or cupriavidus and organisms related thereto
AssigneeInvista North America S.A.R.L.
InventorsAlexander Brett Foster, Jonathan Kennedy
Life of this patent
Estimating the term…
Abstract
Methods for increasing carbon-based chemical product yield in an organism by genetically modifying one or more genes involved in a stringent response and/or in a regulatory network, nonnaturally occurring organisms having increased carbon-based chemical product yield, and methods for use in production of carbon-based chemical products are provided.
Claims20
A method for increasing carbon-based chemical product yield in an organism, said method comprising modulating activity of one or more polypeptides or functional fragments thereof involved in a stringent response and/or in a regulatory network of an organism selected from a species of Cupriavidus or Ralstonia with diminished polyhydroxybutyrate synthesis or an organism with properties similar thereto, thereby increasing carbon-based chemical product yield in the organism as compared to an organism without said modulated polypeptide activity.
A nonnaturally occurring organism capable of yielding a carbon-based chemical product, said organism selected from a species of Cupriavidus or Ralstonia with diminished polyhydroxybutyrate synthesis or an organism with properties similar thereto and comprising a modification to one or more polypeptides or functional fragments thereof encoded by a gene involved in a stringent response and/or in a regulatory network of the organism.
Dependencies are inferred from the claim text.