Antibodies to Paliperidone Haptens and Use Thereof
AssigneeJanssen Pharmaceutica NV
InventorsEric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
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Abstract
Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, risperidone and paliperidone in a single lateral flow assay device.
Claims11
A conjugate of a compound of Formula I and an immunogenic carrier, Formula I:
- wherein
- L1 is OC(O)(CH2)n, or O(CH2)n;
- wherein n is 2 or 3;
- L2 is NHC(O),
- or absent;
- and
- L3 is (CH2)mCO2H, or
- wherein m is 0, 1, 2, or 3;
- provided that m may only be 0 if L2 is absent;
- and further provided that when L2 is absent L3 is
A conjugate of an immunogenic carrier and a compound selected from the group consisting of:
- wherein n is 2 or 3;
- and m 0, 1, 2 or 3.
A method of preparing a conjugate comprising contacting an immunogenic carrier with a compound selected from the group consisting of:
- wherein n is 2 or 3;
- and m 0, 1, 2 or 3.
Dependencies are inferred from the claim text.