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US 2019/0338046 A1Published application
Binding proteins and methods of use thereof
AssigneeNGM Biopharmaceuticals, Inc.
InventorsKalyani MONDAL, Betty Chan LI, Yu CHEN, Taruna ARORA, Hugo MATERN, Wenyan SHEN
Life of this patent
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Abstract
The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
Claims18
1-82. (canceled)
An antibody or fragment thereof that binds human beta klotho, which comprises:
- (a) a heavy chain CDR1 comprising SEQ ID NO:1, a heavy chain CDR2 comprising SEQ ID NO:2, a heavy chain CDR3 comprising SEQ ID NO:3, a light chain CDR1 comprising SEQ ID NO:4, a light chain CDR2 comprising SEQ ID NO:5, and a light chain CDR3 comprising SEQ ID NO:6;
- (b) a heavy chain CDR1 comprising SEQ ID NO:28, a heavy chain CDR2 comprising SEQ ID NO:29, a heavy chain CDR3 comprising SEQ ID NO:3, a light chain CDR1 comprising SEQ ID NO:4, a light chain CDR2 comprising SEQ ID NO:13, and a light chain CDR3 comprising SEQ ID NO:6;
- or
- (c) a heavy chain CDR1 comprising SEQ ID NO:38, a heavy chain CDR2 comprising SEQ ID NO:39, a heavy chain CDR3 comprising SEQ ID NO:3, a light chain CDR1 comprising SEQ ID NO:4, a light chain CDR2 comprising SEQ ID NO:13, and a light chain CDR3 comprising SEQ ID NO:6.
1 more element
Dependencies are inferred from the claim text.