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US 2019/0338041 A1Published application
Multimeric cd40 binding molecules and uses thereof
AssigneeIGM Biosciences, Inc.
InventorsRamesh BALIGA, Beatrice Tien-Yi Wang, Dalya Rivka ROSNER, Bruce Alan Keyt
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Abstract
This disclosure provides dimeric, pentameric, and hexameric CD40 agonist binding molecules and methods of using such binding molecules to induce anti-tumor immunity.
Claims44
A multimeric binding molecule comprising two, five, or six bivalent binding units or variants or fragments thereof,
- wherein each binding unit comprises two IgA or IgM heavy chain constant regions or fragments thereof, each associated with an antigen-binding domain,
- wherein at least three of the antigen-binding domains of the binding molecule can specifically and agonistically bind to a CD40 monomer on a cell expressing CD40, and
- wherein the binding molecule can induce CD40-mediated signal transduction in the cell in the absence of a secondary cross-linking moiety.
Dependencies are inferred from the claim text.