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US 2019/0338036 A1Published application
Antibody formulations
AssigneeSantarus, Inc.
InventorsAdam Jeremy Fowler, Craig Michael Bowe, Wayne Curtis Yount, Nathan Jeremy Cobb, Timothy Martin Kelly
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Abstract
Formulations of anti-VLA-1 antibodies are described.
Claims22
1-30. (canceled)
A method of treating a subject comprising subcutaneously administering to said subject an aqueous pharmaceutical composition comprising an anti-Very Late Antigen-1 (VLA-1) antibody at a concentration of about 100 mg/ml to about 225 mg/ml and at least one buffer,
- wherein said anti-VLA-1 antibody comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 4 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 5, and
- wherein said at least one buffer is selected from one or more of at least one histidine buffer, at least one acetate buffer, at least one succinate buffer, at least one citrate buffer, at least one glutamate buffer, and at least one phosphate buffer.
1 more element
Dependencies are inferred from the claim text.