Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof
AssigneeGenentech, Inc.
InventorsJo-Anne Hongo, Angie Yee, Christine Tan, Joyce Lai, Joanne Adamkewicz, John Byon
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Abstract
The invention provides anti-idiotypic antibodies against anti-PD-L1 antibodies and methods of using the same.
Claims47
An isolated anti-idiotypic antibody that specifically binds to an anti-PD-L1 antibody, wherein the anti-PD-L1 antibody comprises:
- (a) a light chain variable region comprising:
- (i) HVR-L1 comprising the amino acid sequence RASQDVSTAVA (SEQ ID NO:1);
- (ii) HVR-L2 comprising the amino acid sequence SASFLYS (SEQ ID NO:2);
- and
- (iii) HVR-L3 comprising the amino acid sequence QQYLYHPAT (SEQ ID NO:3);
- and
- (b) a heavy chain variable region comprising:
- (i) HVR-H1 comprising the amino acid sequence GFTFSDSWIH (SEQ ID NO:4);
- (ii) HVR-H2 comprising the amino acid sequence AWISPYGGSTYYADSVKG (SEQ ID NO:5);
- and
- (iii) HVR-H3 comprising the amino acid sequence RHWPGGFDY (SEQ ID NO:6).
An isolated nucleic acid encoding an anti-idiotypic antibody that specifically binds to an anti-PD-L1 antibody, wherein the anti-idiotypic antibody comprises a heavy chain variable region comprising HVR-H1, HVR-H2 and HVR-H3 and a light chain variable region comprising HVR-L1, HVR-L2 and HVR-L3, wherein:
- (a) HVR-H1 comprises the amino acid sequence SYDMS (SEQ ID NO:35);
- (b) HVR-H2 comprises the amino acid sequence YISSGGGSTYYPDTVKG (SEQ ID NO:36);
- (c) HVR-H3 comprises the amino acid sequence LVYYDYDDAMDY (SEQ ID NO:34);
- (d) HVR-L1 comprises the amino acid sequence SASSSVSYMH (SEQ ID NO:14);
- (e) HVR-L2 comprises the amino acid sequence STSNLAS (SEQ ID NO:
- 15);
- and
- (f) HVR-L3 comprises the amino acid sequence QQRSSYPPTF (SEQ ID NO:16).
An isolated nucleic acid encoding an anti-idiotypic antibody that specifically binds to an anti-PD-L1 antibody, wherein the anti-idiotypic antibody comprises a heavy chain variable region comprising HVR-H1, HVR-H2 and HVR-H3 and a light chain variable region comprising HVR-L1, HVR-L2 and HVR-L3, wherein:
- (a) HVR-H1 comprises the amino acid sequence DYIML (SEQ ID NO:43);
- (b) HVR-H2 comprises the amino acid sequence NINPYYGSTSYNLKFKG (SEQ ID NO:44);
- (c) HVR-H3 comprises the amino acid sequence WGGNYEGWFAY (SEQ ID NO:42);
- (d) HVR-L1 comprises the amino acid sequence HASQGISSNIG (SEQ ID NO:20);
- (e) HVR-L2 comprises the amino acid sequence HGTNLED (SEQ ID NO:21);
- and
- (f) HVR-L3 comprises the amino acid sequence VQYAQFPLTF (SEQ ID NO:22).
An isolated nucleic acid encoding an anti-idiotypic antibody that specifically binds to an anti-PD-L1 antibody, wherein the anti-idiotypic antibody comprises a heavy chain variable region comprising HVR-H1, HVR-H2 and HVR-H3 and a light chain variable region comprising HVR-L1, HVR-L2 and HVR-L3, wherein:
- (a) HVR-H1 comprises the amino acid sequence SYDMS (SEQ ID NO:51);
- (b) HVR-H2 comprises the amino acid sequence YISSGGGSTYYPDTVKG (SEQ ID NO:52);
- (c) HVR-H3 comprises the amino acid sequence TIYYGYDDVMDY (SEQ ID NO:50);
- (d) HVR-L1 comprises the amino acid sequence SASSSVSYMH (SEQ ID NO:26);
- (e) HVR-L2 comprises the amino acid sequence STSNLAS (SEQ ID NO:27);
- and
- (f) HVR-L3 comprises the amino acid sequence QQRSGYPPTF (SEQ ID NO:28).
Dependencies are inferred from the claim text.